To report an ADE to Pfizer, call: 1-800-366-5288.ADE's should also always be reported to the FDA at: 1-888-332-8387 (or 1-888-FDA-VETS). 

8/31/99 Death #63/Update to Case #68: Dog Is Euthanized Following Liver Toxicity 
Breed: Spaniel/Border Collie mix (female, "Jipsy") 
Age: 12 years 
Reason for Rimadyl rx: arthritis 
Dog's weight and dosage taken: 55 lbs; 50 mg/2x daily; subsequently reduced to 25mg every other day 
When reaction occurred following initial dose: 2 1/2 years; initially prescribed on 2/28/97 
Date of episode: several days 
Symptoms: liver toxicity detected by blood tests 
Date of death: 7/14/99 
Remarks on Dog's Rimadyl Experience: "Jipsy's kidneys had failed; she could not retain any food or produce any urine. She was dying before my eyes. Her collapse was attributed to complications from liver toxicity, which was confirmed by blood tests. 7/10/99 blood test measured alk phos - 7440 (normal range 5-131), creatinine- 2.8 (normal range 0.5-1.6). 7/14/99 levels were alk phos - 10490, creatinine - 8.6. She was euthanized on July 14. Autopsy determined kidneys appeared nearly normal; liver was grainy and gristly with scar tissue, but contained no apparent tumors." 
kbheaton@swbell.nett  

9/21/99 Death #62: First Vet Diagnoses Pancreatitis; Vet #2 Correctly Diagnoses Rimadyl Toxicity, but It Is Too Late 
Breed: Shepherd/Collie mix (male, "Rosco") 
Age: 7 years 
Reason for Rimadyl rx: slight inflammation in neck and head causing pain in front legs 
Dog's weight and dosage taken: 65 lb. 50mg 2x daily 
When reaction occurred following initial dose: 3 days 
Symptoms: vomiting, inappetance, inability to keep water down, progressed to jaundice, liver toxicity, pancreatitis and renal failure 
Date of death: September 19, 1999, 5:05 p.m. 
Vet informed about side effects and informed you? Absolutely not; in fact, I wasn't even told Rimadyl was being prescribed. The vet said, "We'll give him an anti-inflammatory." 
Remarks on Dog's Rimadyl Experience: "The first vet poo-pooed my Rimadyl theory when Rosco first got sick. I was told it was acute pancreatitis, most likely caused by overindulgance in fatty foods. The day he was prescribed the Rimadyl, complete bloodwork was done. All levels were normal. Ten days later (after having been on Rimadyl for only 3 days), his Bilirubin level was sky high (9.0, normal level is 0.1 to 0.3) All liver enzyme, ALT, AST were also through the roof, along with lipase and amylase. He was admitted to hospital (first vet) and treated with IV fluid. Spent one night then sent home, asked to come back next day, then sent home, then finally admitted and kept for 5 days. Sent home and quit eating 3 days later. Was totally disgusted with vet #1 and found vet #2, who suspected Rimadyl almost immediately (even before I had voiced my concerns). He admitted Rosco to his hospital and treated him for renal failure. I hoped and prayed Rosco would pull through, but he did not make it. My personal goal at this point is to ensure that no other pet owner or pet suffers this way. I found out too late that the only miracle about Rimadyl is that it's a miracle if your dog survives it." 
oclair@steptools.com 

9/10/99 Death #61: Toxic Symptoms Appear Suddenly; Dog Dies within 18 Hours 
Breed: Standard Poodle (male, "Torbec's Animation Chenook Corley") 
Age: 11 years, 8 months 
Reason for Rimadyl rx: seemed to have pain in hips when trying to stand up on back legs 
Dog's weight and dosage taken: about 80 lb, 1 tablet daily; later increased to 2 tablets daily (Note: Dog was not overweight, just very large -- 30 inches at the shoulder) 
When reaction occurred following initial dose: not specified 
Symptoms: no outwardly observable reaction until sudden appearance of blood in urine, stool and vomit 
Date of death: August 31, 1999 
Vet informed about side effects: Either he did not know or was playing dumb to protect himself. 
Remarks on Dog's Rimadyl Experience: "We took Chinook to the vet immediately when blood appeared in his urine, stool, and vomit. He died about 18 hours after the symptoms first appeared. The autopsy showed very little wear and tear on his hips. In fact, the vet stated that they looked very good for a dog his age. However, his liver, kidney, and pancreas were severely damaged. The vet stated that he didn't know how the dog had lived that long with that condition. The fact is he had not had the condition very long: a blood test two months prior to his death indicated that all his organs were functioning normally, except for his liver, on which the reading was 20 points above normal. The vet said that was very good for a dog his age. It is my belief that the Rimadyl was doing cummulative damage all along and simply did not show itself until the last moment, when it was much too late to do anything about it." 
corley.paul@worldnet.att.net 
Additional Remarks: "Is any legal action being taken now to get this killer off the market? All of Chenook's siblings are still alive and in good health. I'm sure many are feeling the same heartbreak I am. It seems to me that many great dogs have been made to suffer or die because of Rimadyl. Something must be done to insure this drug is removed from the market and the manufacturer does not profit from the damage they have done." 
corley.paul@worldnet.att.net 

8/11/99 Death # 60: Disclaimer in Rimadyl Ad Is Too Little, Too Late for Six-year-old Savannah 
Breed: Black Lab (female, "Savannah") 
Age When Rimadyl Reaction Occurred: 6 years 
Reason for Rimadyl rx: joint stiffness 
Dog's Weight & Dosage: 90 lbs; dosage not specified 
When reaction occurred following initial dose: 4-6 weeks 
Symptoms: lethargy, general malaise, loss of appetite 
Vet informed about side effects: "I was told there were no serious side effects; the only downside to this drug was its cost.  I was told I could have as much as I needed whenever I needed it -- it was that safe." 
Date of death: 9/20/97 
Remarks on Dog's Rimadyl Experience: "When I inquired about Rimadyl in July 1997, it was after seeing a TV commercial. At that time, there was NO disclaimer at the end of the ad.  For the first few weeks on Rimadyl, Savannah seemed better.  She got around more easily and was able to walk with me, swim, chase her frisbee, etc.  When she lost her appetite after about a month, I thought it was due to a recurring ear infection.  Since I had been given such a glowing recommendation about the safety of Rimadyl, I never suspected it might be the cause.  I had even asked about any liver side-effects and was told 'No, absolutely not.' After 2-3 days, she began eating again and for the next couple of weeks, she was fine. On Friday, September 19, 1997, she began acting bad again.  On Saturday, the 20th, she was very lethargic.  She would even go off by herself, which was VERY out of character.  I still didn't suspect the Rimadyl--even if I had, it would have never occurred to me that she was actually dying right before my eyes.  That evening, I suddenly couldn't find her anywhere.  When I finally discovered her, she had gone into my shower in the bedroom and was cold as ice, and barely breathing.  We rushed her to the vet; she lasted about 2 minutes after we got her inside.  Needless to say, I was devastated and totally confused.  It didn't take long for me to figure out what had happened.  I reported the death to the prescribing Vet and also to Pfizer.  I refused to have her autopsied; we'd all been through enough, and there is no doubt in my mind as to what she died of.  I'm appalled that the lives of these animals and the hearts of their owners are being sacrificed on the altar of Pfizer's bottom line.  The next time I saw the ad for Rimadyl, there was a disclaimer at the end, warning of side effects.  Too little, too late for Savannah.  I still miss her; she was my best girl for nearly 6 years." 
beaner@aug.com 

8/9/99 Death #59: Vets' Disagreement Causes Delay in Treatment and Fatal Result 
Breed: Terrier Mix (female, "Soda") 
Age: 13 years 
Reason for Rimadyl rx: arthritic condition 
Dog's weight and dosage taken: 40 lbs, 50 mg 2x daily 
When reaction occurred following initial dose: 2 weeks 
Symptoms: inappetance, vomiting 
Date of death: July 9, 1999 
Vet informed about side effects: NO; absolutely not! 
Remarks on Dog's Rimadyl Experience: "After two weeks on Rimadyl, Soda exhibited some seemingly minor symptoms. She was eating less than usual (which we attributed to some dental work done on June 10). Then on June 23, she began to vomit occasionally. We took her into the Veterinary Clinic on June 24. Ironically, one of the two veterinarians we saw commented that it wasn’t likely to be the Rimadyl causing Soda’s symptoms. One of the veterinarians requested blood work; however, the senior veterinarian overruled that suggestion and we were sent home. Soda continued to vomit and I took her back the next day. She was then hospitalized with IV fluids; the diagnosis was 'liver necrosis.' We were told it was a 'rare' side effect of Rimadyl. What followed was a fiasco of incompetence and delays. We ended up changing veterinarians over it. Soda did better with our present veterinarian. She seemed to go into a remission that lasted four days. Then the vomiting returned and we took her back for more IV fluids and treatment. We watched helplessly as our beloved Soda’s bright spirit faded. She was not able to fight the toxic effects of Rimadyl. In the end, we assisted Soda by way of euthanasia." 
fineline@telusplanet.net 

9/19/99 Update on Death #59 -- Autopsy Report Establishes Rimadyl Toxicity as Cause of Death 
Excerpts from Soda's necropsy report: "The liver was small and diffusely mottled red/white. The cut surface of the liver had a similar appearance. . . . All sections of the liver are similar in revealing widespread degeneration and necrosis with variable inflammation. The changes are uneven in their severity with large areas affected by complete necrosis ... " Veterinarian Dr. Less McCurdy stated, following a review of the necropsy report: "The fact that Soda's liver enzymes on June 10, 1999, were normal would rule out any pre-existing liver disease. This combined with the necropsy report provides compelling evidence of a Rimadyl toxicity."  

8/8/99 Death #58: Dog Reacts to Dosage Increase after Five Months on Rimadyl; Is Euthanized 
Breed: Labrador/Terrier Mix (female, "Te'y," short for "Teddy") 
Age: about 12 years 
Reason for Rimadyl rx: Had recently developed arthritis and shaky legs 
Dog's weight and dosage taken: about 70 lb, 75 mg 2x daily 
When reaction occurred following initial dose: negative signs about 5 months after first dose 
Symptoms: lethargy, vomiting, depression (not really herself), inappetance, panting, minimal exercise caused exhaustion, refusal to stand, yellow eyes, bloating, eating rocks; liver and kidney enzymes skyrocketed 
Date of death: August 7, 1999 
Vet informed about side effects: NO; she never informed us of any. We asked her the night before our Te'y was euthanized if Rimadyl caused the liver and kidney failure, and she assured us it didn't. 
Remarks on Dog's Rimadyl Experience: "When we first began Rimadyl, it seemed like a miracle. Te'y had energy that seemed to come out of nowhere. The shaking in her legs stopped, and her arthritis seemed non-existent. Since she was doing so well, after a couple of months, we decided to drop her dosage to once per day. Then she began getting shaky and didn't enjoy her walks. The vet told us to go back to twice per day. That was a week before her death. After we returned to two doses per day, she stopped eating, and all of the above symptoms appeared quite suddenly. Her last night she began vomiting what little food she ate. We rushed her to the vet; the diagnosis was liver and kidney failure. Her body was filled with toxins, which made her eyes yellow. She was in a great deal of pain. The vet said she would keep her there overnight to make her as comfortable as possible. The next morning we returned to the vet's office and had her put to sleep. It was the only thing we could do for her. That same night I found the reports on Rimadyl and was struck by how similar other stories were to Te'y's experience. Even though the vet now says Te'y's death wasn't from Rimadyl because, unlike other cases, her liver was enlarged, I still can't believe there was no connection. Her symptoms fit too perfectly. I believe her death could have been prevented if the vet had told us about this. But now it is too late. There never will be another Te'y. I would like to to add that I understand Rimadyl works wonders for many dogs. I wouldn't want to discourage people from using it, but I would encourage them to be informed about the possible side effects." 
terrylumsden@sprintmail.com   

8/6/99 Death #57: Vet Makes Diagnosis of Gastric Torsion; Necropsy Shows Symptoms Consistent with Toxic Reaction to Rimadyl 
Breed: Chow Mix (female, "Maggie Mae") 
Age: 5 years 
Reason for Rimadyl rx: pulled ligament 
Dog's weight and dosage taken: 70 lb, 75 mg 2x daily 
When reaction occurred following initial dose: 4 weeks 
Symptoms: violent vomiting; inappetance; paralysis on last day of her life 
Date of death: July 18, 1999 
Vet informed about side effects: NO; insisted Rimadyl could not cause side effects 
Remarks on Dog's Rimadyl Experience: "Maggie was in very good health until Rimadyl. A week before she died, her appetite diminished. We thought it was due to the hot weather. When she began vomiting violently, I called our vet, who told me to give Maggie Pepto Bismol. She vomited that as well a short time after we gave it to her. I asked the vet if he thought Rimadyl could be the cause. He said, 'No way.' Maggie seemed to be getting progressively weaker, so on Sunday morning, we drove her 35 miles to the emergency clinic. Her blood pressure was so low, they couldn't even get a blood sample from her. The emergency clinic vet really worked to save her, but, at 4:00 that afternoon, Maggie died. I had been a loyal client of my vet for 30 years, but he's lost me now. He kept insisting that Maggie's death was caused by gastric torsion until the necropsy report came back. He finally called to tell us that the necropsy showed the kind of evidence that is consistent with Rimadyl toxicity. We miss Maggie so much. We raised her on a bottle. There will never be another Maggie." 
phoneswa@zebra.net  

8/6/99 Correction/Update to Death #19: Abby, Only 5 Years Old, and One of the First to Die of Rimadyl Toxicity; Case Shows Rimadyl Can Be Fatal to Dogs with Undersized Liver 
Breed: Black Lab (female, "Abby") 
Age: 5.5 years 
Reason for Rimadyl rx: wrist injury 
When reaction occurred following initial dose: 2 weeks during first episode; 2 days during second episode that resulted in death 
Symptoms: vomiting; inappetance; listlessness; elevated liver enzymes 
Date of death: July 14, 1997 
Vet informed about side effects: NO; did not suspect Rimadyl in first episode, so prescribed again 
Remarks on Dog's Rimadyl Experience: "What my vet and I did not realize was that the vomiting and lack of appetite were related to liver dysfunction brought about by a toxic reaction to   

7/16/99 Update to Death #42: 
Suspect Only 10% of Deaths from Rimadyl Are Reported 
"Many vets I know have changed their screening procedures and follow up due to Eliza's and other Rimadyl-related deaths.  At the kennel I use, of a total of 8 or 9 dogs on Rimadyl, all but one died not long after being put on the drug. None but Eliza's have been reported. This leads me to suspect that only about 10% of the actual deaths from Rimadyl are being reported.  It has been eight months since Eliza's death; I will never forget. It was such a violent, horrible death. Along with many people I know, I have turned to acupuncture, chondroitin sulfate, glucosamine, vitamins C and E and chiropractic treatment -- and away from prescription drugs." 
Breed: Greyhound (female, "Eliza Jane") 
Age: 9 years 9 months 
Reason for Rimadyl rx: suspected pinched nerve 
When reaction occurred following initial dose: 5 weeks 
Symptoms: bruising, blood in ear, vomiting and urinating blood (progressive over 5 days) 
Date of death: November 9, 1998 
Vet informed about side effects: Vet is as informed as possible--told me about possible liver problems, initial blood work done 
Remarks on Dog's Rimadyl Experience: "Necropsy results in short: no bone cancer; hemolytic anemia (drug induced cannot be ruled out).  One vet at Pfizer said she sees two of these a month.  How many more go unreported? It seemed to be no big deal to her.  Two a month is small compared to how many dogs take this medication is what I was told.  Well, it is a big deal to me. I am dismayed by the lack of concern of vets who attribute deaths and reactions to old age, or simply tell their distraught clients that tests to prove Rimadyl was the cause are too expensive. If I was in their place, I would pay for the tests. As a health care provider, I would want to know if a drug I was prescribing did have these kinds of side effects. I have heard from the vets that updates they receive from Pfizer downplay side effects. I think Pfizer needs to be responsible in giving drug information to the vets, and should provide printed material for the vets to give to owners of dogs receiving this drug." 
Burpdog@email.msn.com 
Complete Report   

7/16/99 Correction/Update to Death #19: Abby, Only 5 Years Old, and One of the First to Die of Rimadyl Toxicity; Case Shows Rimadyl Can Be Fatal to Dogs with Undersized Liver 
Breed: Black Lab (female, "Abby") 
Age: 5.5 years 
Reason for Rimadyl rx: wrist injury 
When reaction occurred following initial dose: 2 weeks during first episode; 2 days during second episode that resulted in death 
Symptoms: vomiting; inappetance; listlessness; elevated liver enzymes 
Date of death: July 14, 1997 
Vet informed about side effects: NO; did not suspect Rimadyl in first episode, so prescribed again 
Remarks on Dog's Rimadyl Experience: "What my vet and I did not realize was that the vomiting and lack of appetite were related to liver dysfunction brought about by a toxic reaction to Rimadyl. Abby came through that episode and returned to normal, as far as we knew. When she reinjured the wrist in early June, I gave her the Rimadyl for two days and the vomiting began again. I thought she had an upset stomach. Unbeknownst to me and my vet, Abby was born with a liver that was too small for her body. This is why she had the fatal reaction to Rimadyl. This birth defect (an undersized liver) is common, and Rimadyl can be fatal in those animals in which it appears. My vet told me that it is very hard to know if a dog has an undersized liver. Liver function blood panels will show normal levels, as was the case with Abby when she had her annual exam one month before starting on Rimadyl. The only way to be certain of the liver size is to have an ultrasound performed and, unfortunately, that is only done when a problem appears." 
LMOORHD@aol.com  

7/15/99 Dog Is Euthanized Following Liver Toxicity 
Breed: Spaniel/Border Collie mix (female, "Jipsy") 
Age: 12 years 
Reason for Rimadyl rx: arthritis 
Dog's weight and dosage taken: 55 lbs; 50 mg/2x daily; subsequently reduced to 25mg every other day 
When reaction occurred following initial dose: not specified 
Date of episode: not specified 
Symptoms: liver toxicity detected by blood tests 
Date of death: 7/14/99 
Remarks on Dog's Rimadyl Experience: "Jipsy was euthanized yesterday. 7/10/99 blood test measured alk phos - 7440 (normal range 5-131), creatinine- 2.8 (normal range 0.5-1.6). 7/14/99 levels were alk phos - 10490, creatinine - 8.6. Autopsy determined kidneys appeared nearly normal; liver was grainy and gristly with scar tissue, but contained no apparent tumors." 
5/21/99 Case #68: Liver Toxicity Detected While on Rimadyl 
Remarks: "My dog was both overweight and arthritic. My veterinarian prescribed thyroid medication and Rimadyl. Follow-up bloodwork showed improved thyroid levels but also detected liver toxicity. We withdrew Rimadyl, and her liver levels returned to normal. However, her arthritis worsened. I was instructed to resume Rimadyl as before, but have chosen to give her 25 mg every other day instead. She also gets a Cosequin tablet daily and sleeps on a special mat. She's lost 20 pounds, her energy level is good, and she moves more easily, but is still stiff on arising." 
kbheaton@swbell.nett  

6/10/99 Death #56: Kidney Failure Potentially Linked to Rimadyl; Dog's Quality of Life Improved, but Informed Choice Remains an Issue 
Breed: Mixed Sheltie & Terrier (male, "William") 
Age: 15 Years 
Reason for Rimadyl rx: .shoulder socket too big for femur head 
Dog's weight and dosage taken: 28 lbs; not sure of dose 
Length of time on Rimadyl: 8 months 
Symptoms: total renal shutdown; highest protein levels vet had ever seen in a living dog 
Date of death:.May 6, 1999 
Did vet seem informed & inform you about side effects?: Mentioned potential stomach problems; disputed my concerns about other symptoms 
Remarks on Dog's Rimadyl Experience: "I was advised by my vet to put William on Rimadyl to relieve his joint discomfort (which really was quite bad). After he was on it for 8 months, I had William back to the vet for a check up and the vet stated his protein was high at 75; normal was around 15 - 20. He placed him on IV's to flush him out. The vet told me the diet I was feeding William was too rich in protein and specifically red meat. He put him on some awful dried dog food that William would not eat. I forced him to live on that diet for two months then allowed him to return to a normal diet. In May he became lethargic. I was afraid he was just getting old quickly. Over the period of two weeks he got progressively worse. I was already questioning the capability of my vet from past visits. I had to go out of town and my sister (a nurse) kept William. By this time he had stopped eating altogether. She forced fluids and he seemed to stabilize. On Wednesday he got worse and she took him to her vet. When he arrived, the vet placed William on IV's and began running tests. Within two hours, William had a seizure and died. I told the vet when I went to pick him up that I felt William had been poisoned with the Rimadyl. He said he checked the Internet and that the drug was absolutely not the cause. There was NO documented proof that Rimadyl had any severe side effects, he said, and that people who had spread this information were misinformed and had misused the Internet data." (Coordinator's note: Pfizer literature about Rimadyl clearly cites renal effects.) "I feel terribly guilty. I put William on the drug to enhance his quality of life; and it did. I wish however that someone would have informed me of the severe side effects so that I could have made a more informed decision. I don't really know if I had it to do over again whether I wouldn't still give him the drug, but I would have monitored the side effects more closely. I firmly believe that quality of life is more important than quantity, but informed decisions are critical when dealing with a beloved pet." 
RMWATL@AOL.com 

5/28/99 Death #55: No Warning of Rimadyl's Side Effects Given to Family of 3-Year-Old Newfoundland 
Breed: Newfoundland (male, "Yukon") 
Age: 3 years 
Reason for Rimadyl rx: limping after romp with older brother 
Dog's weight and dosage taken: 140 lbs, 300 mg daily 
When reaction occurred following initial dose: 6 weeks 
Symptoms: inappetance, vomiting (food and water), black tarry stools, urinating in house, change of daily habits (where he slept), difficulty climbing steps, lethargy 
Date of death: May 28, 1999 
Did vet seem informed & inform you about side effects? No. He gave us no indication whatsoever there were any adverse effects related to Rimadyl. 
Remarks on Dog's Rimadyl Experience: "The symptons were subtle, yet we knew something was not right. We called the vet the third day or so of vomiting. He told us to administer Pepto Bismol, and, if there was no improvement, to come into the office in the morning. In the morning, Yukie was dead. In all, it was about a week that he wasn't 'up to snuff.' The vet did a preliminary autopsy and said that, in 30 years of practice, he had never seen a liver like it -- 1/4 to 1/3 of the size it should be, pitch black and covered in nodules. This was a healthy, beautiful animal just two months ago who was reduced to his final days in confusion. I don't need to tell you the void he's left. I cry my eyes out missing him. We were NEVER told of ANY side effects of this RIMADYL. Had we been told that there was even a slim chance of liver damage, we would NOT have given it to him. It wasn't worth the risk when compared to a limp we felt would eventually go away. We damn ourselves as well as Yukie's vet. But, in all honesty, we realize the vet may not have known. Our much-loved boy is gone - nothing will bring him back. PLEASE, please, please mark RIMADYL off your list of drugs for a faithful companion. I would not wish the heartache and self-doubt that we've felt on anyone." Update June 7, 1999: The lab report on Yukon's liver was not definitive. Neither the attending vet nor Pfizer can identify Rimadyl as the cause of Yukie's death. The Pfizer vet suggested that the dog may have had a pre-existing condition that was exacerbated by taking Rimadyl and has offered Pfizer's help in covering the expenses associated with his death. 
mwdwrd1642@aol.com  

5/13/99 Death #54: Dog Is Euthanized Following Toxic Reaction to Two Doses of Rimadyl; No Baseline Tests Done; No Side-Effects Warning Given 
Breed: Golden Retriever (male, "Jamie") 
Age: 14 1/2 years 
Reason for Rimadyl rx: arthritis, lameness 
Dog's weight and dosage taken: 75 mg prescribed 2x daily 
When reaction occurred following initial dose: after two doses 
Symptoms: heavy panting; paralysis; neurological damage; seizures 
Date of death: May 12, 1999 
Did vet seem informed & inform you about side effects? "I was not given any information about the drug by the vet, and no baseline tests were performed." 
Owner's Comments: "I am heartbroken. My Golden Retriever, Jamie, had to be put down yesterday. He was prescribed Rimadyl for arthritis. He had 2 doses of 75 mg. each, one on Monday night and one on Tuesday morning. On Tuesday morning, I noticed that he went to his water bowl for his usual morning drink, but turned away and walked back to sleep some more. We then went for our daily morning walk. I was pleased to see that he actually swam a little in his favorite pond; his recent lameness had made him a little reluctant to trust himself in the water. I thought that perhaps the Rimadyl was already helping. I left for work at about 12:30; when I returned five hours later, Jamie was panting heavily and could not get up. His front legs were stiff and his rear legs were flacid. I called the vet who had prescribed the Rimadyl and was told he had probably just overdone his exercise. I took him to an animal hospital in another state (we live in Vermont) and was told he was suffering from neurological damage and seizures, and the kind thing to do would be to put him down. I was told he was in a lot of pain. There were x-rays taken. They revealed that Jamie had a tumor in his spleen and one in his lung. I knew his prognosis was not good anyway and so agreed reluctantly to have him put to sleep. I just can't believe that two mornings ago, my dog was swimming and rolling around in the grassy meadow in the beautiful spring sunshine, and now he is gone. I believe that Rimadyl caused the seizures and neurological symptoms. I know Jamie wouldn't have lived a good deal longer with his cancer, but he was so panicked by the fact that he could not get up. His death was so traumatic for me; it is a nightmare that I just can't get over, especially since I didn't know about the side effects of the drug. I feel as though I killed him with my ignorance. I am just so hurt and angry that my good companion had to die in such a terrible way, and that I let him down." 
GretchenMcCabe@mail.newsbank.com   

5/13/99 Death #53: Rimadyl Suspected in Death of Doberman; No Baseline Tests Done; No Side-Effects Warning Given 
Breed: Doberman (female, "Gracie") 
Age: 13 years 
Reason for Rimadyl rx: trouble climbing stairs 
Dog's weight and dosage taken: 75 mg 2xdaily 
When reaction occurred following initial dose: 3 weeks 
Symptoms: inappetance; refusal to drink; paralysis; liver and kidney failure; internal hemorrhaging 
Date of episode/death: April 8 - May 4, 1999 
Did vet seem informed & inform you about side effects? no baseline tests done; no warnings given of side effects 
Owner's Comments: "My father's dog, Gracie, was a healthy 13-year-old Doberman with no major health problems.  On 4/8/99, my father took her to the vet for her annual check-up. Everything was fine, except that she was having some trouble with her hind legs, going up and down the stairs.Vet gave Rimadyl 75mg. twice a day for one week but did not take blood work or describe any side effects. On 4/13/99, due to improvement in Gracie, my father bought enough Rimadyl for 30 days. The vet felt that she probably had a pinched nerve. On 4/30/99, Gracie had trouble getting up from a lying position and would not eat or drink. My father called the Vet and was immediately told to stop the Rimadyl and to bring her in the next day. On 5/1, Gracie needed to be carried to the vet, where she was admitted, put on IV fluids. Bloodwork was done and X-rays taken.  On 5/3, when my father went in to visit Gracie with her favorite food, she still would not eat or drink. My father questioned the Vet about Rimadyl toxicity and he stated that he did not think that was the problem.  On 5/4, the Vet called my father at 7:30 to inform him that Gracie's condition had deteriorated rapidly, there was blood in her urine, and she was going into liver and kidney failure. He said that her condition was very poor and chances of recovery were not good and recommended euthanasia. We went to get Gracie and transferred her to a large teaching animal hospital close to our home, for a second opinion. By the time we got there, we believe it was too late. I informed this Vet that we strongly suspected Rimadyl toxicity. He told us that at that point she was bleeding internally with no clotting at all, and she was in complete liver and kidney shut down. Both the blood pressure and temperature were very low. The Vet recommended euthanization, and we agreed. Gracie died on 5/4/99. It was on 5/1/99, that I found this website and could not believe how many of the incidents were so similar to Gracie's." 
nlp1752@earthlink.net 

5/2/99 Update on Death #7: Owner of Dog Who Died from Rimadyl Toxicity Now Works as a Vet Tech 
"After losing my dog, Deter, to Rimadyl toxicity, I quit a business management position and became a vet tech so that I could learn more about the care of animals and about drug reactions. Deter became ill May 26, 1997, and died a month later. feel like I killed him because I was uninformed. The clinic I work for is a state-of-the-art facility. I was very impressed, and even during my interview I told about my experience with Rimadyl. I was told that such a reaction was very, very rare; the clinic had never had a dog have a reaction. Subsequently, I saw at least half a dozen dogs come in exhibiting sudden inappetance, swollen abdomen, kidney and renal failure, anemia, etc. Every one of these dogs was on Rimadyl, yet not once did any of the doctors consider Rimadyl to be a cause. Their reaction was, 'That's strange; there seems to be some type of abdominal or spleen mass.' The dogs either died or were euthanized. When I asked about possible Rimadyl reactions, I was told 'Pfizer has not contacted us in reference to side effects. We have never received official notice from Pfizer on this.' It is clear that they still haven't received any, since just last week I had my Lab/St. Bernard Mix in for toenail removal. They prescribed Rimadyl for pain without giving it a second thought! I had tried Rimadyl for him before on the recommendation of a very good friend who is a vet. Within 8 hours, he suffered labored breathing and had become aggressive. Needless to say he did not receive any more of it. " 
BArring370@aol.com 

5/2/99 Update on Death #3: More Comments from Owner of Dog Who Died from Rimadyl Toxicity 
"The following is a link to the Pfizer PetNet site and product information about Rimadyl. The side effects are listed. Don't vets read them? 

http://www.petnet.com/rimadyl/info.asp 

"We had been managing my dog's aging kidneys for two years with diet and hydration with good results. I specifically asked about Rimadyl's side effects on her kidneys and was told by my vet that Rimadyl was processed in the liver. After reading more about Carprofen and its effect on the kidneys, I again mentioned it to the vet. He repeated the same thing -- only this time, he sounded a bit irritated. All the symptoms I subsequently reported to him were attributed to age. With what I know today, I would not put any elderly dog on Rimadyl. The biggest risk factor for any NSAIDs is age. Euthanasia would have to be the only alternative for me to use Rimadyl." 
bjsinclair@earthlink.net 

4/26/99 Death #52: Chow Turns Aggressive Toward Owner; Is Euthanized Following Suspected Toxic Reaction to Rimadyl 
Breed: Chow (male, "Winnie the Pup") 
Age: 5 years, 4 months 
Reason for Rimadyl rx: arthritis, hip dysplasia 
Dog's weight and dosage taken: 62 lbs; 100 mg initially; 50 mg for short period; 100 mg at time of death 
When reaction occurred following initial dose: almost immediately; owner tried withdrawing drug, but vet maintained it could not cause the symptoms dog was exhibiting, so drug was continued 
Symptoms: severe diarrhea, listlessness, inappetance, confusion, exhaustion, severe digestive problems 
Date of episode/death: Died April 15, 1999 
Did vet seem informed & inform you about side effects? NO!! NEVER!! 
Owner's Remarks: "The vet put him on regimen after regimen of antibiotics. He told me that he had colitis. Winnie was also getting Adequan injections every 2 or 3 months which worked great until Rimadyl was added. The vet put him on Canine I/D diet and had me take him off wet food and withdraw treats. Winnie was so depressed. I got a second opinion and the next vet increased his Rimadyl dose to 100mg and gave him a wormer, even though Winnie's worm test were negative. Vet said that parasites don't show up on worm tests. I told the vet that I didn't like the way I thought Rimadyl was affecting my dog, and they told me that it WAS NOT THE DRUG! Winnie the Pup was diagnosed with hip dysplasia when he was a puppy. He had two torn ligments in his knees and had two knee surgeries about a year apart. He did great and recovered quickly. As he got older, he started getting a little stiff, especially at night, so the vet prescribed Rimadyl. He was on 50mg. I immediately noticed that he became lethargic and depressed. I took him off the drug because he was so unhappy. The next vet visit, the vet told me that the Rimadyl was not the cause and he put him back on it. Winnie started to have chronic diarrhea and went downhill fast. He became confused on his walks and started to limp. The whites of his eyes were not white. On Easter Sunday 1999, I was sitting on the floor playing tug with Winnie. Suddenly, he growled and attacked me. He bit one side of my nose completely off. He had never exhibited aggressiveness of any kind in his entire life. I have had to have reconstructive surgery (a six-hour operation). But, worst of all, Winnie had to be put down while I was in the hospital. After the attack, he didn't even recognize my sister. I AM DEVASTATED at the loss of my dog. NO ONE EVER told me of the potentially dangerous side effects of Rimadyl. This lack of information has cost the life of my dog and has left me with permanent physical and emotional scars. I have contacted Pfizer and told them I want it to be mandatory that all vets across the country print out a sheet with all the side effects and tests that are recommeded while the animal is on the drug. And I'm not the kind of person that will let it rest. I don't want anyone else to suffer the way that I have. I feel that I killed my dog with this drug. Anyone is welcome to write to me." 
dudette181@webtv.net 

3/4/99: Death #51: 
Collie with History of Ulcer Is Given Rimadyl 
Breed: Collie (female, "Honey") 
Age: 11 years 
Reason for Rimadyl rx: arthritis pain 
Dog's weight and dosage taken: 90 lbs./100 mgs. 2X day 
When reaction occurred following initial dose: drug had been administered intermittently over several months 
Symptoms: seizures, diarrhea, rash; anemia, internal bleeding 
Date of death: 7/29/98 
Vet informed about side effects?: Vet insisted symptoms were due to old age; said Rimadyl could not cause stomach upset or digestive distress 
Owner's Remarks: "The summer prior to my dog's being given Rimadyl, she had a duodenal ulcer. I almost lost her due to the bleeding. She spent a week at the ICU at Purdue vet school clinic. From then on, we had to be very careful about what medicines she could take for her arthritis. Rimadyl was recommended because, I was told, it would not cause stomach upset or digestive distress. She had been on Rimadyl on and off for a few months. It was withdrawn due to a high fever and rash that developed. What is puzzling is that her bloodwork showed normal levels five days before she died of anemia. Within 3 hours of developing symptoms, she was unresponsive. I repeatedly asked if Rimadyl could be causing this and was told, 'No; its due to old age.' I have not gotten over Honey's death. Eleven years is not old to me. I've had Irish setters live to be 17. Honey was too young, and I blame Rimadyl for her suffering and for her death." 
jmcniven@netnitco.net 

Death #50: 
Collie Dies of Liver Toxicity; No Baseline Tests Done 
Breed: Collie (male, "Logan") 
Age: 7-8 years 
Reason for Rimadyl rx: arthritis pain 
Dog's weight and dosage taken: 78 lbs./100 mgs. 2X day 
When reaction occurred following initial dose: 6 weeks 
Symptoms: Loss of appetite, vomiting, excessive panting 
Date of death: 12/28/98 
Vet informed about side effects?: Vet who prescribed Rimadyl said there were few -to-no known side effects 
Owner's Remarks: "Logan went off his feed Friday evening. Saturday evening, he still refused to eat, and later began vomiting. He died sometime during the night on Monday. Our vet (NOT the one who prescribed Rimadyl) is very hesitant to identify Rimadyl as the culprit, but took my suspicions seriously enough (Logan died of liver toxicity) to call a staff meeting and begin doing preliminary blood work before prescribing the drug in the future. For that I am quite thankful. I suspect that Logan may have already had some type of liver irregularity or disease prior to taking the drug, which predisposed him to the reaction he had, but I can't help but wonder if some preliminary blood work would have revealed that. We lost a very-much-loved family friend. Just wish I'd have done more homework before putting him on it." 
mmkarner@iolok.com 

Death #49: 
Sudden, Painful Death of 11-Year-Old Schnauzer 
Breed: Schnauzer (male, "Spencer") 
Age: 11 years 
Reason for Rimadyl rx: arthritis in rear legs 
When reaction occurred following initial dose: 11 months 
Symptoms: loss of appetite, vomiting blood, lethargy, depression, weakness 
Date of death: 12/30/98 
Vet informed about side effects?: Somewhat, but did not explain the seriousness of them; did preliminary blood work, but did not continue to monitor throughout course of treatment. 
Owner's Remarks: "Even though my vet is noncommittal, I feel certain that the use of Rimadyl is what caused the death of my beloved Spencer. . . .The onset of his symptoms was simply horrible -- he became so lethargic, he would not touch food or water -- and then he vomited blood. The vet tried to overcome the kidney damage that the Rimadyl had done and just could not do it. . . . If I could spare one person the pain that I have gone through, please take this advice: GET YOUR DOG OFF OF THIS DRUG! My dog was healthy, happy, fun-loving, and wonderful to be with.. . . Please -- take care of your pets! Don't let this happen to you!" 
burress@in-motion.net 
(This is an abbreviation of the Complete Report.) 
  
  

Death #48: 
Rottweiler Dies after Vet Increases Rimadyl Dosage Despite Signs of Toxicity 
Breed: Rottweiler (female, "Isis") 
Age: 10 1/2 years 
Reason for Rimadyl rx: limp, possible osteosarcoma 
Dog's weight and dosage taken: 99 lbs, 100mg 1-2 pills twice a day 
When reaction occurred following initial dose: 2-4 weeks 
Symptoms: vomiting, diarrhea, jaundice, urinating in house, blood in urine, anemia-severe, stopped eating, weak-not able to walk 
Date of death: 6 weeks after initial dose, 1/2/99 
Did vet seem informed & inform you about side effects? He said there were some rare side effects but did not tell me what to watch for -- he said mainly gastrointestinal upsets 
Owner's Remarks: "If I had known about these side effects or the vet had told me what to watch for, I would have opted for a different pain reliever. I know that Rimadyl killed my dog prematurely. She was feeling fine and eating well before I gave her those pills. After she showed symptoms, the vet never thought they might be related to Rimadyl and, in fact, told me to increase her dosage. I trusted him completely. I will never do that again, and I will never give Rimadyl to any of my other dogs. My dog suffered a great deal and so did I and my family. We want the drug company to make sure each person using this drug for their dog knows all risks and side effects involved. A pamphlet should accompany each prescription so consumers can make a more informed choice. I still blame myself for giving her those pills and making her so sick." 
linn@halcyon.com 

Death #47: 
"100% Healthy" Cocker Spaniel Dies of Liver Failure 
Breed: Cocker Spaniel (male, "Pete") 
Age: 8 1/2 years 
Reason for Rimadyl rx: arthritis in the middle spine and hip 
Dog's weight and dosage taken: 34lbs/ 37.5mg 2xs day 
When reaction occurred following initial dose: second day; but administration of drug continued intermittently despite appearance of side effects 
Symptoms: vomiting, diarrhea, etc. (see Owner's Remarks below) 
Date of death: 11/3/98 
Did vet seem informed & inform you about side effects? The only side effects mentioned by vet were vomiting and diarrhea.Vet instructed owner to administer Rimadyl with Tagament, Pepto, Kaopectate 
Owner's Remarks: "Pete was on Rimadyl for two weeks in December 1997; it was then given intermittently until May 1998. In May, he was placed on Rimadyl daily with Tagament given at each dose a.m. and p.m. Since he had vomiting and diarrhea, I was told to use Pepto or Kaopectate. His other symptoms: fatigue, urination in the house but refusal to go when outside), depression (we thought because in 9/98 his mate came down with Bell's Palsy), eating less and drinking less (didn't want to take his favorite treats). These symptoms came on slowly and we noted them but were very involved in the care of our other Cocker Spaniel. Fluid build up had started (9/98) and his eating and drinking stopped the weekend before we had to put him to sleep due to cirrhosis of the liver. We took him in to the vet on Monday because of the severity of his symptoms. They suspected liver problems (found a heart murmur) and did a complete blood work up. Tuesday morning he stopped breathing; I did CPR and he did start breathing again. But when we rushed him to the vet, he told us that his liver enzymes were way off and his protein level was almost non-existent. X-rays and sonargram done. Vet told us he was dying and there was nothing we could do but put him to sleep to take him out of his pain. This dog was 100% healthy except for some arthritis prior to going on Rimadyl. Pete was our boy of the family and Rimadyl took his life. Even though we have three other Cocker Spaniels, we still cry for Pete and his senseless death. He will never be forgotten. Perhaps this report of our experience will help some other dogs to avoid Pete's fate." 
Meanst@uswestnet.com 
  
  

Death #46: 
Dog Dies 9 Months after Experiencing Complications from Rimadyl Reaction 
Breed: English Setter (female, "Meggin") 
Age: 6 years 
Reason for Rimadyl rx: lameness 
When reaction occurred following initial dose: 10 days 
Symptoms: vomiting; inappetance; yellow eyes and gums; elevated liver enzymes 
Date of episode: May 1998 
Date of death: January 1999 
Vet informed about side effects: NO 
Owner's Remarks: "Meggin became a diabetic due to pancreatitis brought on by liver failure due to Rimadyl. This in itself is a 'life sentence.' So although she survived Rimadyl, she had to bear (as did I) the daily monitoring, injections, etc., that go along with diabetes. I was so GRATEFUL she was still with me-- but it was not without its high price." 
Update 7/29/98: Dog dianosed with cancerous tumor; surgery extremely hazardous due to liver damage caused by Rimadyl 
Update 1/30/99: "It is with a heavy heart that I write to tell you that my sweet girl Meggin has gone to the Rainbow Bridge today. Her suffering and pain are no more. I know she will be greeted by so many beloved friends there. My heart is broken, but I know it was the final loving gift I could bestow upon her." 
Kimmie651@aol.com 

Death #45: 
4-Year-Old Irish Wolfhound Dies After Only 4-5 Doses of Rimadyl 
Breed: Irish Wolfhound (female, "Ellie") 
Age: 4 years 
Reason for Rimadyl rx: Right front elbow had degenerative arthritis in it. It was not a big problem and had been treated with 1/2 tablet of Aleve for pain with good results. On January 8, the dog suddenly began crying with pain and would not put weight on her right leg. 
Dog's weight and dosage taken: 126lbs. - 125 mg twice daily 
When reaction occurred following initial dose: On January 9, 1999; one day after initial dose 
Symptoms: lethargy, swelling in elbow area, loss of appetite, rapid eye movement, dementia, not responsive, vomiting, heavy panting 
Date of episode: January 8 - 18, 1999 
Date of death: January 18, 1999 
Did vet seem informed & inform you about side effects? "All I was told was to look for vomiting, told that few dogs have a bad reaction. I had picked up a pamphlet on Rimadyl earlier last year because the vet had suggested using it for her arthritis problem. I was not sure I wanted to start her on it because I had heard it could cause kidney problems. I really never read it before this incident." 
Owner's Remarks: "The day the dog was taken in for the initial problem the vet administered an injection of Prednisolone Acetate 40mg IM and sent me home with 125mg of Rimadyl, which I was told to start immediately. The dog slept all day January 8 and started showing bad symptoms on January 9. The vet recommended stopping the Rimadyl on January 10 and to bring her in first thing on the 11th. He observed her all day January 11th and on the 12th told me to get her to the Veterinary Specialty Clinic. They examined the dog, read the x-rays, and sent me home with my dog and told me to again give Rimadyl but 3x's daily now. Never really commented on the dog's other symptoms. By the next day, the dog was throwing up, refused to eat and only received 2 doses of the Rimadyl. The vet at the Specialty Clinic said as long a dog was drinking water he wasn't concerned with her inappetence. Now I started finding blood coming from her nose or mouth. I rushed her into the emergency room at the Specialty Clinic. The next 5 days were hell. She progressively got worse. She was then diagnosed with acute renal and liver failure. Every possible measure was taken to turn things around. On Monday, January 18t, the vet said her creatine levels were at 12 and she was really struggling. My decision was made to let her go. One of the hardest things I have ever had to do." 
tuxfalco@ameritech.net /Darlene Falco 

Death #44: 
Liver Failure Caused Death in 7-Year-Old 
Breed: Not specified (male, "Mr. Max") 
Age: 7 years 
Reason for Rimadyl rx: not specified 
When reaction occurred following initial dose: 3 to 8 months 
Symptoms: Loss of appetite 
Date of death: December 1998 
Vet informed about side effects: No 
Owner's Remarks: "My dog (Mr. Max) was on Rimadyl for 8 months. After 3 months passed, his appetite dropped. Our vet said he had hypothyroidism. This past Monday, after several previous visits to his vet and a weight drop of 10 pounds, I had another vet check him. He was having liver failure at 7 years old! Cause: Rimadyl. Had I known this was a possibility, I would have NEVER given him this medication. I am so hurt and angry at the vet and the makers of this drug. ... I foolishly trusted the vet. Never again." 
12/20/98 

Death #43: 
Breed: Doberman/Lab Mix (female, "Pee Wee") 
Age: 14 years 3 months 
Reason for Rimadyl rx: hip dysplasia, arthritis, spine problems 
When reaction occurred following initial dose: 3 months 
Symptoms: Loss of appetite, excessive panting, inappetance, loss of balance, hot spots, urination in the house, excessive urination 
Date of reaction/death: November 1998; April 5, 1999 
Vet informed about side effects: No 
Owner's Remarks: "Thanks to the advice of a friend I went on a 'net search for Rimadyl. I had my suspicions about the drug and possible negative effects, but my vet chalked up my dog's symtoms to 'old age syndrome' and 'just a little of irritation from it.' " 
roxc@roxaneinc.com 

Death #42: 
Pfizer Sees "Two a Month" of this Type of Reaction 
Breed: Greyhound (female, "Eliza Jane") 
Age: 9 years 9 months 
Reason for Rimadyl rx: suspected pinched nerve 
When reaction occurred following initial dose: 5 weeks 
Symptoms: bruising, blood in ear, vomiting and urinating blood (progressive over 5 days) 
Date of death: November 9, 1998 
Vet informed about side effects: Vet is as informed as possible--told me about possible liver problems, initial blood work done 
Owner's Remarks:"Necropsy results in short: no bone cancer; hemolytic anemia (drug induced cannot be ruled out).  One vet at Pfizer said she sees two of these a month.  How many more go unreported? It seemed to be no big deal to her.  Two a month is small compared to how many dogs take this medication is what I was told.  Well, it is a big deal to me. I am dismayed by the lack of concern of vets who attribute deaths and reactions to old age, or simply tell their distraught clients that tests to prove Rimadyl was the cause are too expensive. If I was in their place, I would pay for the tests. As a health care provider, I would want to know if a drug I was prescribing did have these kinds of side effects. I have heard from the vets that updates they receive from Pfizer down play side effects. I think Pfizer needs to be responsible in drug information to 
the vets, and provide printed material for the vets to give to owners of dogs receiving this drug." 
Burpdog@email.msn.com 
Complete Report 

Death #41: 
Owner Told "No Side Effects" 
Breed: English Springer Spaniel (female, Libby) 
Age: 12 years 
Reason for Rimadyl rx: arthritis in rear legs 
When reaction occurred following initial dose: 2 weeks 
Symptoms: loss of appetite, seizure 
Date of death: December 12, 1998 
Vet informed about side effects: Vet said only side effects were gastrointestinal; said there were no other side effects to watch for 
Owner's Remarks:"She had a checkup prior to beginning the drug and was in good health. At the beginning of the third week on the drug, she lost her appetite. We suspected that Rimadyl was to blame and stopped giving it to her. We started the drug again the following week. On the third day, she refused a treat and began shaking like she was having a seizure. She died on the way to the emergency room. The vet said that he was aware of the toxicity in some dogs but did not tell me since she tolerated the initial dose well. He felt it was a decision that should be weighed: mobility versus possible serious side effects, but he did not inform us and allow us to make the decision. If we had the information we now have, we never would have let our dog take this drug. I believe this drug and the irresponsible way it was prescribed and monitored killed an otherwise healthy dog. The vet said that tests to prove whether Rimadyl actually was responsible for her death would be very expensive. " 
haneylinda@aol.com 
Complete Report 

Death #40: 
Rapid, Frightening Decline and Death of 10-year-old Chow/ Collie 
Breed: Chow/Collie Mix (female, "Tai") 
Age: 10 years 
Reason for Rimadyl rx: arthritis flare-up 
When reaction occurred following initial dose: 10 weeks 
Symptoms: liver and kidney failure 
Date of death: December 6, 1998 
Vet informed about side effects: yes; vet has discussed case with Pfizer and has reported it as an adverse drug experience 
Owner's Remarks:"Tai had perfectly normal lab work in October 1998, as part of her geriatric physical exam. She had a rapid and frightening decline to total liver and kidney failure, which the vet thinks is related to Rimadyl. He has assured me that there was nothing I could have done differently, but it doesn't bring her back or soothe the guilt I feel." 
Coordinator's Note: Of special interest in this report -- The owner is a Registered Nurse specializing in Emergency/ Trauma care, and, based on her background, felt she would be alert to any serious side effects or complications....and that "nothing could get by" her. The dog's decline was too rapid, however. 
Complete Report 

3/12/99 Update on Report of Death #40: 
Necropsy Confirms Rimadyl Toxicity as Cause of Death: "I submitted our story immediately after our dog Tai's death, before receiving confirmation that the changes seen in Tai's liver and kidney specimens were consistent with an adverse reaction to a drug such as Rimadyl or acetaminophen. Since she had not taken acetaminophen, Rimadyl was the only possible cause. My vet has further discussed her case with Pfizer and submitted the entire case report for their review. I have spoken with the FDA myself to insure that they are aware of yet another adverse reaction to Rimadyl. While I am still so heartbroken at the needless loss of this sweet little girl, I must admit that we were lulled into a false sense of security with the drug. Nikko, Tai's sister (littermate), had been on Rimadyl at a higher dosage for 18 months prior to Tai's initial dose. Nikko had no adverse reaction, but was taken off the drug immediately when Tai became ill. We have chosen to try the new Adequan therapy and other non-drug methods to keep her comfortable and active. As noted in the report, I am a nurse, and I am not out to take Pfizer down. Rimadyl has made a significant positive difference in the quality of life in so many dogs. Our experience, however horrible, however agonizing, was indeed an 'adverse event,' in the true scientific use of the term. I can only hope that the experiences that are listed on this website will serve to further educate the public, and bring about better medication and/or options for canine arthritis. My vet has told me that every time he counsels a client on the use of Rimadyl, he can't help but picture Tai in his mind, making him stress vigorously the potential risks along with the benefits. He realizes this is small comfort, but it is also a small positive outcome from a tragic event. Tai will always be in our hearts and will forever reside in our memories." 
DBANNER@SJMC.ORG 

Death #39: 
Breed: Alaskan Malamute (female, "Panda") 
Age: 12 years 2 months 
Reason for Rimadyl rx: severe arthritis in rear legs 
When reaction occurred following initial dose: 3 weeks 
Symptoms: inappetance, refusal to drink, sweet-smellling urine, lethargy, restlessness, partial paralysis 
Date of death: November 28, 1998 
Vet informed about side effects: Somewhat; we brought the symptoms to his attention and discussed them. He was aware that she might have reactions but felt that her arthritis was so bad to begin with that it was inevitable that we would have to put her to sleep. 
Owner's Remarks:"After Panda started on Rimadyl, she seemed to get a little better for a week or so, then got worse. The last few days (3 weeks after beginning the drug), she literally couldn't get up or move and suffered from the symptoms described above. I am positive these were adverse reactions to Rimadyl. It isn't clear exactly how much Rimadyl contributed to her death." 
Galacktus@aol.com 

Death #38: 
Breed: White German Shepherd/Husky ( female, "Princess") 
Age: 13.5 years 
Reason for Rimadyl rx: stiffness 
When reaction occurred following initial dose: 6 months 
Symptoms: inappetance, disorientation, weakness; kidney failure, ulcerated stomach 
Date of death: June 18, 1998 
Vet informed about side effects: did not inform owner 
Owner's Remarks:"Princess was 13 1/2 years old but extremely healthy (before taking Rimadyl). I honestly feel that Rimadyl was the leading cause of my girl's death." 
tsucalam@ms.com 

Death #37: 
Breed: German Shepherd Dog/Wolf mix ( female, "Liebchien") 
Age: 9 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 4 months 
Symptoms: jaundice, inappetance, vomiting 
Date of death: July 17, 1997 
Vet informed about side effects: Rimadyl was new on the market; vet did not know of any side effects 
Owner's Remarks:"The medicine ended up destroying her liver. Her white count was up to 80-90,000 -- about 10 times higher than it should have been. The only hope we had for her was to give her a blood transfusion. It went successfully, but within a day she had a stroke. I was up with her the whole night and the next morning took her to the vet. The vet told us that there was nothing we could do for her. She was already paralyzed from the neck down. She could not urinate, was totally blind in one eye, and was going blind in the other. We put her down so she wouldn't be in so much pain. " 
hugnpaws@webtv.net 

Death #36: 
Rimadyl Side Effects In a Young Dog Go Undiagnosed by Vets for 7 Months 
Breed: English Bulldog (female, "Wilma") 
Age: 5 years 
Reason for Rimadyl rx: bilateral instability in knees, limping, requiring artheroscopic knee surgery in January 1998; casts taken off and dog walked in March 1998 
When reaction occurred following initial dose: within one week 
Symptoms: mini-seizures, twitching in sleep, listlessness, behavioral changes, inappetance, no interest in favorite food/treats, dragging feet to point of bleeding, vomiting, chronic diarrhea (for over 4 months), weight loss, restlessness, stumbling, loss of muscle mass, vaginal discharge 
Date of death: July 23, 1998 
Vet informed about side effects: did not inform owner about any side effects 
Owner's Remarks:"I have written because I want pet owners to know that a reaction to Rimadyl can occur in YOUNG DOGS as well as older dogs. Wilma was a young, healthy dog, as established by a complete physical exam given just weeks before taking Rimadyl. Within 8 days of the original dosage, symptoms began and did not stop until her death 7 months later. I believe the dosage she was on -- 100 mg -- was too high to begin with (she weighed 47 pounds). I took Wilma to eight different vets; none ever suspected Rimadyl. When I finally found a wonderful vet who ran an array of tests, it was too late. Wilma had advanced liver dysfunction and quickly withered away. If I had only known the side effects to look for, I might have been able to save her life. I firmly believe that Rimadyl killed my dog, but, since her remains are in an urn, there is no proof. TOTAL COST of pet care since on Rimadyl: just under ten thousand dollars. PLEASE NOTE: Reaction to Rimadyl can happen to younger pets, too -- and it can happen quickly. " 
Otlynne@aol.com 

Death #35: 
Breed: Pembroke Welsh Corgi (male, "Dewey") 
Age: 3 years 
Reason for Rimadyl rx: limp, front leg 
When reaction occurred following initial dose: 8 weeks 
Symptoms: loss of appetite, incontinence, seizure, hemorrhage 
Date of death: August 1997 
Vet informed about side effects: NO 
Owner's Remarks:"Dewey was euthanized due to liver hemorrhage. He was only three and the adored pet of two small children." 
hugnpaws@webtv.net 

Death #34: 
(Coordinator's Note: It is particularly important to note here that, while Rimadyl toxicity is supposedly rare, two dogs in one family experienced identical reactions to the drug. One died and the other is permanently disabled.) 
Breed: Not specified (male, "Beau") 
Age: senior 
Reason for Rimadyl rx: arthritis pain 
When reaction occurred following initial dose: 7 months 
Symptoms: staggering, falling, eyes twitching 
Date of death: March 1998 
Vet informed about side effects: NO! Definitely NOT! 
Owner's Remarks:"I had tragic results using Rimadyl on two of my dogs. Beau began taking Rimadyl in February or March of 1997. He was doing well on other pain medication, but the vet thought Rimadyl offered the possibility of Beau's achieving a return to a more active life. One night in September 1997, he woke me, crying out in pain. By the next morning, he was staggering and falling. I had never seen anything like it. When I got him to the vet, she was perplexed. Beau's eyes were twitching rapidly. She said it could be anyone of several problems. After a few days, his staggering was not quite as severe, but from that first night until the day he had to be put to sleep in March of this year, he had to be carried outside. Because my vet did not know about the incidence of these symptoms related to Rimadyl, Beau was not taken off the drug until November, by which time he was so weak he was taken off all medication." (Coordinator's Note: See Case #1 below about this owner's other dog, "Rudy," and also read the Complete Report for additional important details.) 
troost@webtv.net 

Death #33: 
Breed: Chocolate Lab (male, "Buck") 
Age: 13 years 
Reason for Rimadyl rx: severe arthritis 
When reaction occurred following initial dose: 1 year, 8 months 
Symptoms: vomiting, depression, loss of appetite, lethargy, loss of balance 
Date of death: September 29, 1998 
Vet informed about side effects: only after first blood work done, 6 months ago 
Owner's Remarks:"Buck had a long up and down battle with arthritis. Approximately three weeks ago, I started giving him 2 doses of 75 mg Rimadyl tabs a day, three days a week, at the recommendation of his vet. He began to show all the symptoms listed above. I took him in to see the vet. . . . He was put on an IV for about 20 hours. Complete kidney failure was diagnosed. Yesterday, I signed the form and said good-bye to my best friend. Now I sit here, after two hours of gathering information, wondering if this drug may have caused his death. I believe this drug did help relieve the pain and discomfort, but at what cost? . . . A part of me is gone...I miss Buck very much." 
WGould1007@aol.com 

Death #32: 
Formerly Case #32 
Breed: Not specified (female, "Gip") 
Age: 12 years 
Reason for Rimadyl rx: spinal problems, dysplasia, arthritis 
When reaction occurred following initial dose: 6 weeks 
Symptoms: suspected stroke 
Date of death: September 1998 
Vet informed about side effects: yes; did blood work 
Owner's Remarks:"I took Gip off the Rimadyl after about 6 weeks because there seemed to be something wrong. It seemed as though she had had a stroke. She went blind in one eye. . . . I don't know if the Rimadyl did this to her, but I have to report this so others can be warned . . . If I had to do it all over again with the information I now have, I would never have given her Rimadyl. They don't know enough about it. I miss my Gipper very much and don't want anyone to have to go through what we just did." 

Death #31: 
Breed: Not specified (male) 
Age: 12 years 
Reason for Rimadyl rx: arthritis in hips 
When reaction occurred following initial dose: 3 weeks 
Symptoms: refusal to eat, lethargy 
Date of death: March 1998 
Vet informed about side effects: did not inform owner of any side effects; diagnosed renal failure, but did not relate it to Rimadyl 
Owner's Remarks: "My twelve year old dog refused to eat in early March. The veterinarian fed him by IV and took blood tests. The tests showed that he had advanced renal failure. The veterinarian mentioned that a week of intensive care at a hospital might help, although the prognosis was poor. I remember my dog being really reluctant to get out of the car to see the veterinarian on that last morning. He was in such low spirits. Based on the renal failure, I made the decision to have him put to sleep, but, since that time, I wonder if I did the right thing. Was it just a Rimadyl reaction that could have been reversed? The treatment cost was not really a factor. He was a dog, but I loved him so much. I keep wondering if I did the right thing." 
Norman H. West 

Death #30: 
Breed: Chow Chow (female, "Arejay") 
Age: 10 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 5 days 
Symptoms: diarrhea, dark stools, vomiting, lethargy 
Date of death: May 22, 1998 (one day after appt. with vet) 
Vet informed about side effects: NO; owner told this was a very "safe" drug 
Owner's Remarks: "I had seen the advertisement of the drug on TV and had hoped this would help Arejay be more comfortable. She did great for a couple days and then got worse. The vet said to take her off the drug. I took her in a few days later. The vet said she was fine. She died the next night. The vet, I think, doesn't believe that it was Rimadyl that caused her death, but, from all the information that I have read, I am sure that I would still have Arejay today if it weren't for Rimadyl." 
xena.rook@attws.com 

Death #29: 
Breed: Airedale (male, "Skipper") 
Age: 15 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 2 years 
Symptoms: lethargy; restlessness; excessive thirst; panting 
Date of death: July 1998 
Vet informed about side effects: owner not warned 
Owner's Remarks: "Did Rimadyl give Skipper an additional two years of being able to walk, or did it blow his kidneys and immune system? I will most likely never know.My personal goal, for Skipper and all of our pets, is to get the Rimadyl folks to put, in plain English, the major warning signs right on the bottle. Just like tobacco. They should be listed on the container. PERIOD. " 
Tom_Maher@legis.state.ak.us 
Complete Report 

Death #28: 
Breed: Chow (male, "KiBear") 
Age: 10 years 
Reason for Rimadyl rx: hip dysplasia 
When reaction occurred following initial dose: 7 months 
Symptoms: lethargy; restlessness; excessive thirst; panting 
Date of death: July 1998 
Vet informed about side effects: told owner, "Honey, nothing in these pills can hurt him" 
Owner's Remarks: "Ki was a very healthy dog...well loved and well cared for. I never gave him more than two tablets a day, but there were days I did give him two. I wish I could go back and 'undo' the last seven months, but, knowing that is impossible, I hope this warning about Rimadyl might help others. " 
KenJo1214@aol.com 

Death #27: 
Breed: Miniature Schnauzer (female, "Josie") 
Age: 11 years 
Reason for Rimadyl rx: athritis 
When reaction occurred following initial dose: 4 months 
Symptoms: inappetance; lethargy; kidney failure 
Date of death: July 1998 
Vet informed about side effects: did not inform owner 
Owner's Remarks: "In my ignorance, I thought giving her the pill when she was obviously not feeling well would help her feel better -- relieve joint ache, etc. The vet prescribed 1 - 2 pills a day when she first started on it. I gave her one per day; however, I doubled up when she starting showing signs of being ill. Josie had never been sick before." 
janee@txalum.com 
Complete Report 
Additional Notes on Death #27: 
October 17, 1998: "My vet gave us the Rimadyl without my asking -- for a little stiffness in rear legs (she had some trouble jumping on the bed!) . I was not told of any side effects or symptoms to look for. Josie began panting a lot and was restless at night... My vet ... said it was probably just a cramp... He was concerned, but could find nothing wrong -- again, did not mention the Rimadyl she was taking. I continued to give her the Rimadyl ... she would just stand at her water bowl and look it it, obviously wanting water, but did not drink. I had to carry her outside; then she would want to immediately come back in. The vet ran complete tests on her and found her to be in total renal failure. He tried to fill her with intravenous fluids all weekend to flush her out. We lost her in 2 days. Rimadyl was the only drug she ever took." 
janee@txalum.com 
Complete Report 

3/16/99:Addendum to Report of Death #27: 
Miniature Schnauzer 
The dog's breed and age were omitted from the original "complete report." "Josie" was a Miniature Schnauzer, born 7/9/87. She had never been ill until she developed symptoms of Rimadyl toxicity, which went undiagnosed. She died of total renal failure on 7/12/98 at age 11. A growing number of Miniature Schnauzers are reported to have suffered Rimadyl toxicitiy. 
janee@txalum.com 

Death #26: 
Breed: Golden Retriever (male, "Brandon") 
Age: 12 years 
Reason for Rimadyl rx: athritis 
When reaction occurred following initial dose: 11.5 months 
Symptoms: lethargy; panting 
Date of death: July 1998 
Vet informed about side effects: did not inform owner 
Owner's Remarks: "I haven't had the heart to call the vet to find out the final results of the tests they ran, and what really was the cause of his illness. Anyway, I'm still suspicious of Rimadyl, and feel that we weren't fully informed about the side effects and risks involved. " 
djoneses@cts.com 

Death #25: 
Breed: Schipperke (male, "AWOL") 
Age: 15.5 years 
Reason for Rimadyl rx: athritic front paw 
When reaction occurred following initial dose: 8 months 
Symptoms: lethargy; inappetance; fullness in abdomen 
Date of death: July 1998 
Vet informed about side effects: NO 
Owner's Remarks: "NO bloodwork was recommended prior to giving my AWOL Rimadyl, and I received no warnings about side effects. In hindsight, I was stupid for not insisting on bloodwork, and I was even MORE stupid to put my healthy, hardy old Schip on Rimadyl for a minor achey paw." 
robert217@jps.net 

Death #24: 
Breed: Labrador (female, "Bados") 
Age: 9 years 
Reason for Rimadyl rx: athritis 
When reaction occurred following initial dose: 21 days 
Symptoms: violent vomiting 
Date of death: October 1997 
Vet informed about side effects: NO 
Owner's Remarks: "To this day, too many vets and dog owners are uninformed about the change in labeling for Rimadyl. Unsuspecting dog owners are still being told by uninformed vets that Rimadyl does not have any side effects. Pfizer should be more proactive in effectively informing vets and dog owners about the reactions that apparently were not experienced in the pre-approval clinical studies. If the information is not getting to the vets in the first place, or the vets are not deeming it important, it's not a very effective way to communicate. We view that as a severe breakdown in communications, which, unfortunately, directly affects unsuspecting third parties. How can one weigh the risk/benefit ratio with this drug (or any drug) when all the information is not provided or understood?" 
BADOS@AOL.COM (Complete Report) 

Death #23: 
Breed: Chocolate Labrador (male, "George") 
Age: 9-10 years 
Reason for Rimadyl rx: athritis 
When reaction occurred following initial dose: 23 days 
Symptoms: inability to walk; inappetance; vomiting 
Date of death: October 1997 
Vet informed about side effects: NO 
Owner's Remarks: "I will not stop trying to alert people of the serious and deadly side effects of this sinister drug. It can strike a dog in a few days or it can strike months later. I will say that people have contacted me and said it has indeed been a miracle for their dogs. For them, I think that is wonderful. But just keep your eyes open and you and your vet be aware of all of the side effects to look for. And, it is wrong for a vet to prescribe this medicine to any dog without doing preliminary testing and blood workups." 
LuSwinton@aol.com (Complete Report) 

Death #22: 
Breed: German Shepherd Dog (male, "NorRhoda's Condor") 
Age: 9 years 
Reason for Rimadyl rx: limp 
When reaction occurred following initial dose: 1 - 19 days 
Symptoms: mild gastrointestinal symptoms after first day; cleared up after 3 days; then, after 2 weeks exhibited lethargy, excessive urination, dark urine, heavy panting 
Date of death: July 1998 
Vet informed about side effects: did not inform owner 
Owner's Remarks: "What I want to get across is this: Rimadyl CAN cause death in a short time. It doesn't take months. Vets aren't warning people about possible side effects and what to look for. The FDA needs to change the packaging requirements so that the end user gets the insert, rather than the veterinarian. Don't discount symptoms because they aren't severe or sudden. I was caught unaware by relatively mild symptoms that gradually worsened." 
howards@po-box1.edwards.af.mil 

Death #21: 
Breed: Yellow Lab (female, "Jessie") 
Age: 11.5 years 
Reason for Rimadyl rx: hip dysplasia 
When reaction occurred following initial dose: 8 months 
Symptoms: inappetance; violent hemmorhaging 
Date of death: March 1998 
Vet informed about side effects: vet said "few side effects, if any"; did not warn owner of nature of side effects 
Owner's Remarks: "My veterinarian said this was her first experience with a Rimadyl- related death, but all three pathology reports pointed to Rimadyl being the cause. The frightening part of this was that Jessie's blood work came back absolutely normal, so, even if she had been monitored all along, it would not have shown anything." 
CPoulos409@aol.com 

Death #20: 
Breed: Yellow Lab (female, "Chelsea") 
Age: 13.5 years 
Reason for Rimadyl rx: mobility problems 
When reaction occurred following initial dose: 6 weeks 
Symptoms: vomiting; inappetance; listlessness; elevated liver and kidney enzymes 
Date of death: March 1998 
Vet informed about side effects: vet said drug was intended for older dogs; had minimal side effects 
Owner's Remarks: "I am writing this to you not as a sad story, but as a topic I believe should be presented. I've heard more people say how wonderful this new drug is, and while Pfizer maintains there are few known side effects, my friend is dead. Vets are telling their clients that there are no side effects, or that the side effects are too minimal to worry about. There ARE side effects, and they need to be addressed. Perhaps Chelsea is only one of the 4% of dogs experiencing known side effects, but she was not one of their 'control' animals -- she was a member of our family who is now deeply missed." 
Colleen Gerrior 

Death #19: 
Breed: Black Lab (female, "Abby") 
Age: 5.5 years 
Reason for Rimadyl rx: wrist injury 
When reaction occurred following initial dose: 2 weeks during first episode; 2 days during second episode that resulted in death 
Symptoms: vomiting; inappetance; listlessness; elevated liver and kidney enzymes 
Date of death: July 14, 1998 
Vet informed about side effects: NO; did not suspect Rimadyl in first episode, so prescribed again 
Owner's Remarks: "What my vet and I did not realize was that the vomiting and lack of appetite were related to liver dysfunction brought about by a toxic reaction to Rimadyl. She came through that episode and returned to normal as far as we knew. When she reinjured the wrist in early June, I gave her the Rimadyl for two days and the vomiting began again. I thought she had an upset stomach. I had no idea what was happening to her liver. Unbeknownst to me and my vet, Abby was born with a liver that was too small for her body. This is why she had the fatal reaction to Rimadyl. This birth defect (an undersized liver) is common and Rimadyl can be fatal in those animals in which it appears. My vet told me that it is very hard to know if a dog has an undersized liver. Liver function blood panels will show normal levels, as was the case with Abby when she had her annual exam one month before starting on Rimadyl. The only way to be certain of the liver size is to have an ultrasound performed and, unfortunately, that is only done when a problem appears." 
LMOORHD@aol.com 

Death #18: 
Breed: Yellow Lab (male, "Butch") 
Age: 5 years 
Reason for Rimadyl rx: limp 
When reaction occurred following initial dose: 2 weeks 
Symptoms: depression; vomiting; mucoid diarrhea; inappetance 
Date of death: October 1997 
Vet informed about side effects: "We would have never given it to him if we had known it would kill him. The side effects we were told to watch for were diarrhea and vomiting. Nothing life threatening." 
Owner's Remarks: "My husband and I want to know who is going to take responsibility for our dog's tragic death. We hope that, if enough people tell their stories, something will change dramatically in the way Rimadyl is being prescribed. No other dog or family should ever have to go through what we and a significant number of other people have." 
3/9/99 Correction to Report of Death #18: 
Improper Warning of Side Effects 
The Horn family wrote: "I haven't been to this website in a long time since my family has been unable to talk about the loss of our Butch. We were reading the new format for the reports and found an error in our story. It says, "YES," that we were informed of the side effects of Rimadyl. That is not correct. We would never have given it to him if we had known it would kill him. The side effects we were told to watch for were diarrhea and vomiting. Nothing life threatening. I wish all dog lovers would visit this website." Jim Horn 
(Coordinator's Note: We sincerely apologize to the Horn family for the inaccuracy in our original report of Butch's death from Rimadyl.) 
Andover 4@aol.com 

Death #17: 
Breed: St. Bernard (female, "Brandy") 
Age: 6.5 years 
Reason for Rimadyl rx: hip dysplasia 
When reaction occurred following initial dose: 6 weeks 
Symptoms: vomiting; inappetance; listlessness 
Date of death: February 16, 1998 
Vet informed about side effects: YES; baseline tests not done, however 
Owner's Remarks: " As far as we knew, Brandy never had any kind of problem with her health -- only this mobility problem that prompted us to start her on Rimadyl in the first place. She was a perfectly healthy dog. I feel that it is my fault that she has died. If I had not given her those pill, she would be alive today. She trusted me and I let her down. The makers of Rimadyl need to know the devastating side effects that are occurring with this medication. I know that some dogs are doing well on it. But is there a hidden time-bomb waiting to go off? My poor dog died alone in a kennel at the vet's. I pray to God that she did not suffer. She was alone and we had no chance to say goodbye. I would advise anyone considering using this medication to be very cautious and THINK ABOUT IT." 
momp@netins.net 

Death #16: 
Breed: Yellow Lab (female, "Sundae") 
Age: 8.5 years 
Reason for Rimadyl rx: osteoarthritis 
When reaction occurred following initial dose: 6 months 
Symptoms: vomiting; inappetance; listlessness 
Date of death: September 1997 
Vet informed about side effects: not clear; initial diagnosis was "jaundice and auto-immune hemolytic anemia" 
Owner's Remarks: " September 14 - Sundae put to sleep. Rimadyl was not a compassionate treatment for our dog. Autopsy done. Conclusion, Rimadyl-induced death. Pfizer gave us no assistance in suggesting treatment. Pfizer was given Sundae's autopsy report and had access to Sundae's tissue samples for more study. Pfizer did not take the opportunity to further study why Sundae reacted so fatally to Rimadyl and why we were cheated out of many more years with our best friend." 
Robin_Fletcher@hp.com 

Death #15: 
Breed: Springer Spaniel (female, "Murphy") 
Age: 7.5 years 
Reason for Rimadyl rx: hip dysplasia 
When reaction occurred following initial dose: several months 
Symptoms: listlessness, then collapse; bloody diarrhea; internal hemmoraghing 
Date of death: March -September 1997 
Vet informed about side effects: if so, did not warn owner 
Owner's Remarks: " Murphy had been a healthy, happy dog, and within 24 hours she was dead.  My veterinarian will not confirm that Rimadyl was related to her death.  Nor was any other cause ever established.  I certainly cannot say for sure it was Rimadyl. But, after hearing other stories, I remain suspicious, and would never put another dog on the drug.  Please warn others to be cautious.  I would never want another dog to suffer as Murphy did.  She was my best friend and companion. I will miss her always." 
lseldeen@antioch.sbceo.k12.ca.us 

Death #14: 
Breed: Samoyed (female, "Cassie") 
Age: 12 years 
Reason for Rimadyl rx: mild arthritis 
When reaction occurred following initial dose: 6 months 
Symptoms: inappetance; collapse 
Date of death: September 1997 
Vet informed about side effects: if so, did not warn owner 
Owner's Remarks: "We had a necropsy done. The vet who looked at her liver was doing research on Rimadyl-related deaths. He said that her liver was consistent with what he'd seen in Rimadyl-related deaths. Cassie's quality of life was wonderful until her death. I know the Rimadyl helped her...until it killed her." 
DeniNation@aol.com 

Death #13: 
Breed: Lab/Hound Mix (female, "Ginger") 
Age: 16 years 
Reason for Rimadyl rx: mild arthritis 
When reaction occurred following initial dose: 7 months 
Symptoms: whimpering; aimless crawling; dark urine 
Date of death: August 1997 
Vet informed about side effects: if so, did not warn owner 
Owner's Remarks: "I believe Pfizer needs to re-examine their instructions and recommended dosage. I don't believe this is a lifetime drug. If using it for a prolonged period of time, you are playing Roulette with your dog's life. Caution must be used. I lost one dog to Rimadyl but managed to save another." (See Case #19, below.)" 
almgtsvcs@cchat.com 

Death #12: 
Breed: Shelty (male, "Duffy") 
Age: 12.5 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 15 days 
Symptoms: stumbling; vomiting; inappetance; weakness 
Date of death: December 1997 
Vet informed about side effects: YES; however, in face of severe dehydration, would not guarantee owner that dog would recover 
Owner's Remarks: "I have not been in contact with my vet since I picked up Duffy's ashes; it's painful even to drive past the clinic. So I don't know if he is aware of all this new evidence. I think Pfizer has a long way to go to make it up to people whose beloved pets were 'sacrificed' to their new 'wonder drug.' I don't know how their clinical trials were conducted, but, from what I see, they didn't 'finish their homework' before unleashing this drug onto unsuspecting pet owners." 
Jcquiltb@aol.com 

Death #11: 
Breed: Rottweiler (female) 
Age: 7 years 
Reason for Rimadyl rx: torn anterior cruciate ligament 
When reaction occurred following initial dose: 4 months 
Symptoms: vomiting; collapse; bloody stool 
Date of death: April 1998 
Vet informed about side effects: not clear; rehydration attempted, but unsuccessful in reviving dog 
Owner's Remarks: "This dog was my baby, my friend and my life. In trying to help her, I believe I loved her to 'death.' I am convinced that this was NSAID toxicity." 
Pitbulover@aol.com 

Death #10: 
Breed: Yellow Lab (female) 
Age: 15 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 6 weeks 
Symptoms: bloody stool; inappetance; lethargy; vestibular signs 
Date of death: Spring 1998 
Vet informed about side effects: not clear; diagnosed stroke 
Owner's Remarks: "I still believe that the Rimadly sent her on a downward spiral and accelerated her death." 
Rmebrat72@aol.com 

Death #9: 
Breed: Terrier/Poodle (female, "Cricket") 
Age: 15 years 
Reason for Rimadyl rx: neck pain 
When reaction occurred following initial dose: 24 hours (3 doses) 
Symptoms: vomiting; disorientation; collapse 
Date of death: April 1998 
Vet informed about side effects: YES; owner told of side effects but not severity 
Owner's Remarks: "She had been given 3 doses (1/2 tablet each dose) of Rimadyl, and then she was gone! I have no medical proof that Rimadyl was my dog's killer, since no tests were performed either before or after her death. But Cricket had most of the life-threatening symptoms that are listed. This is not a wonder drug for every dog. Had I known anything about this drug ahead of time, maybe I would have known what to look for sooner and possibly could have saved her life." 
toyzunlimited@sprynet.com 

Death #8: 
Breed: Collie Mix (female, "Samantha") 
Age: 13 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 2 months 
Symptoms: vestibular syndrome; seizures 
Date of death: Winter 1997- May1998 
Vet informed about side effects: not clear 
Owner's Remarks: "Is there a way to know for sure whether the Rimadyl was the cause of her sudden devastating illness? If there is, I would like to know, because, for now, I have to live with the knowledge that, if it is indeed the cause, I put those pills in her mouth twice a day. If it was Rimadyl, the result was not pain relief from arthritis, but, instead, repeated seizures that caused my girl to scream and cry as she seizured uncontrollably, often falling into her own vomit. I'll hear those screams as long as I live. I'm going to miss her so." 
jlcwirtz@mindspring.com 

Death #7: 
Breed: American Pointer/English Setter Mix (male, "Deter Dog") 
Age: 4 years 
Reason for Rimadyl rx: hip dysplasia 
When reaction occurred following initial dose: 1 month 
Symptoms: lethargy; appearance of having gained weight; panting; distress; pale gums 
Date of death: June 1997 
Vet informed about side effects: not clear; no bloodwork done; vet wanted to perform exploratory surgery to determine cause 
Owner's Remarks: "His regular veterinarian (not the one who prescribed Rimadyl) discussed all options with me in great detail and prolonged Deter's life for exactly one month. For this I am very grateful. When I had asked him about Rimadyl and possible reactions to it, he told me it was very possible. He gave me an insert from the Rimadyl package and, sure enough, it stated that it could cause hemorrhaging and severe anemic reactions. Well, on June 25, 1997, my Deter finally was laid to rest. His kidneys were gone and his liver permanently damaged. My poor baby had suffered so much in his last month of life. The weight he seemed to have gained was nothing more than his blood that filled his body cavity. His urine was filled with blood, as was his stool. He panted heavily and constantly. Approximately two days before he died, he quit eating all together. I am very upset that, out of all the large veterinary clinics, none of them even considered the Rimadyl theory." 
BArring370@aol.com 

Death #6: 
Breed: Mix (female) 
Age: 13 years 
Reason for Rimadyl rx: mild arthritis 
When reaction occurred following initial dose: 1 month 
Symptoms: hemorrhage 
Date of death: June 1997 
Vet informed about side effects: vet attributed symptoms to "old age": no warning of side effects given to owner 
Owner's Remarks: "The worst part about it is that her stiffness was not that bad. If I had been warned that a side effect might be DEATH, I would have thought twice, and then twice more before giving her Rimadyl." 
mattm@vastnet.net 

Death #5: 
Breed: American Standard Pit Bull (male, "Crackers") 
Age: 14 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 3 months 
Symptoms: stumbling; loss of balance; seizures; elevated liver enzymes 
Date of death: March 1997 
Vet informed about side effects: NO; treated dog with anti-seizure medication that made symptoms worse 
Owner's Remarks: "The vet performed a total blood analysis and everything looked good except an abnormality of his liver enzymes. Apparently she isn't aware of the problems associated with this drug. Had I found out this information earlier, maybe I could have saved Crackers." 
Linda Beaupre 

Death #4: 
Breed: Dalmatian (male, "Luka") 
Age: 6 years 
Reason for Rimadyl rx: torn ligament 
When reaction occurred following initial dose: 5 days 
Symptoms: vomiting; inappetance; lethargy; elevated liver & kidney enzymes; seizures 
Date of death: February 1998 
Vet informed about side effects: told owner Rimadyl involvement was doubtful; 
Owner's Remarks: "The autopsy did not reveal too much of anything either; possible pancreatitis. I was told that it was not due to Rimadyl toxicity. I find this hard to believe, after I've done so much research on this medication. Unfortunately all the research was done after it was too late; if only I had done some before I started giving this medication." 
jmc.west@worldnet.att.net 

Death #3: 
Breed: Toy Poodle (female) 
Age: senior 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 3-4 months 
Symptoms: panting, restlessness 
Date of death: Spring 1998 
Vet informed about side effects: did not inform owner of potential side effects; attempted to "flush" drug from dog's system, but could not 
Owner's Remarks: "I gave my little dog Rimadyl for months, not knowing the potential side-effects." 
JS, in Michigan 
Additional Comments on Death #3: 
"We lost our beloved dog 6/8/98. In addition to coping with the aging process, she had to cope with Rimadyl toxicosis. She turned into a zombie after 8 months on the drug. We know now that she was showing intolerance after two weeks, but everything we reported to the vet was shrugged off. He even increased the dose after a few months to 'make her feel better.' Vets believe Pfizer hype and don't believe pet owners. . . When I send messages to magazines, vet newsletters, and columnists, I include a link to the Practitioners' Reporting Network, because PRN is not pet owners with 'anecdotal stories' that too many shrug off; it's vets reporting to the Network about adverse reactions that subsequently led to Pfizer's having to make a label change. Be sure to click on this link to see what vets have reported about Rimadyl:http://www.usp.org/pubs/review/rev_063b.htm " 
bjsinclair@earthlink.net 

Death #2: 
Breed: Bichon Frise (female, "Mitzi") 
Age: 6 years 
Reason for Rimadyl rx: arthritis 
When reaction occurred following initial dose: 2 weeks (1 week after Rimadyl stopped) 
Symptoms: blood in urine; listlessness; inappetance; excessive urination; excessive drinking; vomiting 
Date of death: July 1998 
Vet informed about side effects: diagnosed bladder infection and prescribed Tribrissen 
Owner's Remarks: "One of Pfizer's veterinarian's spoke to me on the telephone, was very sympathetic about our dog's swift decline and subsequent demise but feels that she did not die due to Rimadyl poisoning. I readily admit that none of us (the vets, the rep from Pfizer, my husband or myself) can actually say what happened. All I know is that many of the symptoms were identical to the suffering and decline of the other animals we've read about who were taking Rimadyl. The Pfizer vet said it could have been a combination of going from the Rimadyl to Tribrissen or that a pre-existing condition could have been worsened. " 
CHNEARY@aol.com 

Death #1: 
Breed: Miniature Schnauzer (female) 
Age: 13 years 
Reason for Rimadyl rx: joint pain 
When reaction occurred following initial dose: 3-4 days 
Symptoms: seizures; walking in circles; vomiting; depression 
Date of death: July 1998 
Vet informed about side effects: told owner drug had "virtually no side effects and was very safe in older dogs" 
Owner's Remarks: "My vet told me it was just age, and I should expect this. I asked if it could be the Rimadyl and was told, 'Absolutely not.' I was instructed to continue Rimadyl as directed. I really felt it was the drug causing these reactions, however, not only because my Schnauzer was sick, but also because my Shih Tzu, who was on Rimadyl for a shoulder injury, was slowing down, was listless, and had had a change in attitude. " 
ReallyMish@aol.com